Also, the results of the current meta-analysis show that high Ki-67 expression was more common in males (OR = 1.89, P < 0.001), smokers (OR = 2.20, P < 0.001), those in later tumor stages (OR = 1.46, P = 0.004), or those with poorer differentiation (OR = 1.47, P = 0.002), which has been linked to more aggressive tumors. Here, MKI67 is linked to neoplasm.