Cells from many cancers overexpress Myc, and this basic cancer signature has been exploited to identify synthetic lethal interactors of hyperactive Myc levels relative to wild-type Myc levels with shRNA/siRNA libraries (Cermelli et al. 2014; Kessler et al. 2012; Liu et al. 2012; Toyoshima et al. 2012). This evidence concerns the gene MYC and cancer.