It is known that besides the classical role of vitamin D in calcium and bone homeostasis, vitamin D is linked to numerous non-skeletal diseases due to the elucidation that most cells, including the pancreatic beta-cells and cardiomyocytes contain the vitamin D receptor (VDR), and most of them also have the capability to produce the biologically active 1,25-dihydroxyvitamin D for paracrine functions [22, 23]. The gene discussed is VDR; the disease is bone disorder.