Multiple logistic regression analysis of known predictors of CAD confirmed the independent role of smoking status (P < 0.001), diabetes (P = 0.001), obesity (P = 0.001), hyperlipidemia (P < 0.001) and ApoA1 (P < 0.001) as risk factors of CAD (Table 1). Here, APOA1 is linked to obesity due to melanocortin 4 receptor deficiency.