BMP15 and osteochondritis dissecans: In addition, disruptive mutations affecting the same gene may not always have the same phenotypic consequences, as outlined in our study of BMP15: In a previous study (29), a rare, heterozygous, missense mutation was shown to lead to OD due to abnormal processing of the precursor BMP15 protein, which resulted in precursor dimers and/or precursor-mature peptide heterodimers.