In the KP, the HR for the statistical interaction between HHEX_23-AA and diabetes was 4.79 (95% CI 1.63–8.90, p = 0.013) for dementia and 3.55 (95% CI 1.45–9.91, p = 0.025) for AD after adjustment for age, sex, education, baseline MMSE score, follow-up survival status, BMI, heart disease, stroke, SBP, DBP, and APOE ε4. This evidence concerns the gene APOE and heart disorder.