APOE and Alzheimer disease: In the KP, multi-adjusted Cox regression analysis showed that the AA genotype in combination with diabetes was associated with a substantial risk of dementia (HR 5.54, 95% CI 2.40–7.18) and AD (HR 4.81, 95% CI 1.88–8.50) compared to the GG genotype without diabetes after controlling for age, sex, education, baseline MMSE score, BMI, heart disease, stroke, SBP, DBP, APOE ε4, and follow-up survival status.