Production of CCL17, CCL1, chemokine (C-X-C motif) ligand-13 (CXCL13) and CXCL8 (IL-8) has been shown to be associated with the activation program for M2 tumor associated macrophage (TAM), and is parts of mononuclear phagocyte-mediated regulatory circuits of innate and adaptive immunity [25]. The gene discussed is CXCL8; the disease is neoplasm.