To date, more than 25 amyloid forming proteins have been identified in disease-associated amyloid deposits, including α-synuclein (α-syn) in Parkinson’s Disease (PD), amyloid-β peptide (Aβ) in Alzheimer’s disease (AD), and prion protein (PrP) in transmissible spongiform encephalopathies [6]. The gene discussed is PRNP; the disease is early-onset autosomal dominant Alzheimer disease.