We report that apoptosis proteins, such as caspase-3, p53, Bcl-2, and macroautophagy-related proteins, such as LC3 and Beclin-1, are significantly regulated in ALS-CSF- and ALS-FTD-CSF-cultured U251 cells. The gene discussed is MAP1LC3A; the disease is amyotrophic lateral sclerosis.