To further evaluate the impact of c-Myc on metformin sensitivity, metformin response in normoglycemic conditions (5.5 mM glucose) was assessed in three ovarian cancer cell lines with MYC gene amplification (Kuramochi, SNU-119, and 59M) and one cell line without MYC amplification (HeyA8) [32]. This evidence concerns the gene MYC and ovarian carcinoma.