The multi-targeted anaplastic lymphoma kinase (ALK) inhibitor crizotinib has demonstrated significant improvement in progression-free survival (PFS) over chemotherapy as both first-line or second-line treatment of ALK-rearranged non-small cell lung cancer (NSCLC) [1, 2] and has firmly established that ALK rearrangement is a targetable driver mutation in NSCLC. Here, ALK is linked to non-small cell lung carcinoma.