A stratified Kaplan-Meier survival analysis further revealed that patients with a lower LMR had a significantly worse survival in the subgroups of age >60 years, tumor size ≤5 cm, right-sided tumors, M0, differentiation grade of G3-G4, no perineural invasion, normal serum CEA levels, KRAS gene mutation, wild-type BRAF and PIK3CA, 18q LOH, and no hMLH1 gene promoter hypermethylation (all p < 0.05; Figure 5; Supplementary Table S4, available online). Here, BRAF is linked to neoplasm.