In vitro studies on the effects of GADD45γ expression on sorafenib-sensitive (Huh-7 and HepG2, IC50 6–7 μM), acquired sorafenib-resistant (Huh-7R and HepG2R, IC50 12–15 μM), and intrinsic sorafenib-resistant (Hep3B, IC50 12 μM) HCC cells are summarized in Figure 1. This evidence concerns the gene GADD45G and hepatocellular carcinoma.