GADD45G and hepatocellular carcinoma: However, GADD45γ induction was more prominent in sorafenib-sensitive HCC cells than in sorafenib-resistant HCC cells and was independent of the MEK/ERK signaling in HCC cells because the RAF inhibitor, ZM336372, or the MEK inhibitor, U0126, could not induce GADD45γ expression (Figure 1A and Supplementary Figure S1).