SETD2 and neoplasm: The average tumor appearance time were significantly decreased in HOTAIR overexpression group (5.34 ± 1.19 days) and increased in STED2 overexpression group (14.85 ± 3.12 days) compared to control (8.22 ± 2.02 days), while the average tumor appearance time were significantly no difference in HOTAIR overexpression plus SETD2 overexpression group (9.1 ± 2.73 days) compared to control (8.22 ± 2.02 days) (P > 0.05) (Figure 8Dc).