Finally, we investigated whether FLT3 inhibitor (PKC412) in combination with ABT737 treatment restore PSL sensitivity more prominently in T-ALL cells with high expression of MEF2C. First, we determined FLT3 expression was much higher in LOUCY than in Jurkat by q-PCR analysis (Fig 5a). The gene discussed is FLT3; the disease is acute lymphoblastic leukemia.