In fact, similar epigenetic changes were observed with the gene that encodes osteoglycin (Ogn), a proteoglycan studied in the context of ectopic bone formation that has recently been implicated in neurite outgrowth.38 Although leptin signaling is particularly interesting in light of its association with anxiety and mood, it is also quite possible that a relatively less studied gene such as Ogn may be important for mood stabilization. This evidence concerns the gene LEP and Anxiety.