As many of the anti-cancer effects of FTY720 are independent of S1PRs and there are possible side effects associated with antagonizing S1P signalling, a non-immunosuppressive FTY720 analogue, OSU-2S was developed that cannot be phosphorylated by SPHK2 and does not induce S1PR1 internalization 98. The gene discussed is MBTPS1; the disease is cancer.