Taken together, these data support the possibility that human CSMD1 variation might play disproportionate roles in schizophrenia vulnerabilities due to influences on the cognitive difficulties that are commonly experienced by individuals with this diagnosis [34], though recent analyses also point to roles for CSMD1 variation in core schizophrenic psychotic features and in disease severity, providing a caution to accepting this simple explanation [16]. Here, CSMD1 is linked to schizophrenia.