CSMD1 and nicotine dependence: The gene that encodes the CUB and sushi multiple domains 1 protein (CSMD1) has been identified in case vs control genome-wide association (GWAS) samples for addiction- related phenotypes that include extensive use of an addictive substance, vulnerability to develop dependence on an addictive substance, ability to quit smoking and time from initiation of tobacco use to development of nicotine dependence.