Best described among these are the FBXW1 (β-trcp1) and FBXW11 (β-trcp2), which have context-dependent roles in cancer and cellular proliferation via the targeting of multiple important transcription factors, second messengers, and receptors which collectively drive proliferative and/or apoptotic phenotypes depending on the cell type and environment [14, 25]. Here, FBXW11 is linked to cancer.