MMP3 and cancer: Hypoxia inducible factor 1, alpha subunit (HIF1A) was downregulated in common in cancer cells (Table 5(b)), while stromelysin-1 (matrix metallopeptidase 3), vascular endothelial growth factor A (VEGF-A), and neuropilin-1 were upregulated in common in fibroblasts (Table 6(a)).