2002; Frota et al. 2009). Our novel findings herein of differential changes in BDNF isoforms in the lumbar spinal cord of RR-EAE mice are aligned with a recent report of dysregulated serum levels of BDNF isoforms in patients with RR-MS (Tongiorgi et al. 2012). Here, BDNF is linked to myeloid sarcoma.