LEP and obesity due to melanocortin 4 receptor deficiency: In the light of the above findings, the objective of this study was to assess the effect of six-month-long physical exercise programme with whole-body cryostimulation as a means to change body composition, lipid profile, adipokine concentration (adiponectin, leptin, visfatin, and resistin), and antioxidant enzyme activity in people with overweight and obesity.