In the light of the above findings, the objective of this study was to assess the effect of six-month-long physical exercise programme with whole-body cryostimulation as a means to change body composition, lipid profile, adipokine concentration (adiponectin, leptin, visfatin, and resistin), and antioxidant enzyme activity in people with overweight and obesity. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.