Frontotemporal dementia and parkinsonism linked to chromosome 17- (FTDP-17-) mediated tau mutations can disrupt lysosomal function in transgenic mice expressing human tau with four tubulin-binding repeats (increased by FTDP-17 splice donor mutations) and three FTDP-17 missense mutations: G272V, P301L, and R406W [169]. Here, MAPT is linked to frontotemporal dementia.