INS and Hyperglycemia: The consequences of hyperglycaemia on cancer cells behaviour can be either direct, as already reported, or indirect, through the increase in the levels of insulin/IGF-1 and inflammatory cytokines in circulation, such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) [49], together with the most classical inflammatory markers such as C-reactive protein [3], but also through oxidative stress generation [50] and platelet activation [51].