Most molecular studies in endometrial cancer have focused on the most common form, uterine endometrioid carcinoma (UEC), which is primarily driven by PTEN loss and mutations in FGFR2, ARID1A, CTNNB1, PIK3CA, PIK2R1, and KRAS [48]. The gene discussed is FGFR2; the disease is endometrial endometrioid adenocarcinoma.