More specifically, a recent study has demonstrated that the FadA protein, a virulence factor expressed by Fusobacterium nucleatum, can signal epithelial cells via E-cadherin, a cell-surface molecule important for CRC metastasis as well as a component of the WNT/β-catenin signaling pathway, the most commonly mutated pathway in CRC [13, 14]. Here, CDH1 is linked to colorectal carcinoma.