In Kupffer cells, releases of several inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β are upregulated in NASH livers, and these expressions are reportedly regulated by nuclear factor-κB (NF-κB) transcriptional activity [4–6]. Here, TNF is linked to metabolic dysfunction-associated steatohepatitis.