In osteoporosis subjects, femoral bone mineral density (FBMD) was negatively correlated with age (R = −0.293, P < 0.01), chemerin (R = −0.395, P < 0.01), FBG (R = −0.388, P < 0.01), and insulin (R = −0.388, P < 0.01). This evidence concerns the gene RARRES2 and osteoporosis.