Genes that were significant with at least two variables include: BTNL2 for alopecia areata, NOD2 for Crohn’s disease, PLA2R1 for membranous neuropathy, LMO1 for neuroblastoma, and TNPO3, UBE2L3, HLA-DRA, and HIC2 for systemic lupus erythematosus. This evidence concerns the gene HIC2 and systemic lupus erythematosus.