Performing IHC using a novel monoclonal antibody specific for CAP37 detected expression of this immune modulator in the polymorphonuclear leukocytes (PMNs) and endothelial cells in both the parietal (Fig. 1a) and temporal lobes (Fig. 1b) of all AD patients and age-matched controls (Fig. 1e, f). This evidence concerns the gene AZU1 and Alzheimer disease.