PTEN and colonic neoplasm: In detail, miR-183 knockdown of tumor cell lines caused deregulation of a miRNA network composed of miR-183-EGR1-PTEN in synovial sarcoma, rhabdomyosarcoma, and colon cancer [29], and the zinc finger transcription factor EGR-1 (early growth response-1), known as a gene essential for growth, proliferation, or differentiation [34], is a direct regulator of PTEN [35].