In the present work and by using a set of well-characterized experimental EC tumor samples, and through a candidate gene approach, we characterized the frequently reported independent region of tumor suppressor activity in human tumors located telomeric to TP53. We subjected all 19 genes located in this chromosomal segment to gene expression analysis in a panel of 28 rat EC and seven control non-malignant endometrium (NME) samples. This evidence concerns the gene TP53 and neoplasm.