AKT1 and cancer: In conclusion, our data suggested Inpp5k and Myo1c as potential candidates located adjacent to each other within the reported independent tumor suppressor loci distal to Tp53. There is no earlier report on their potential involvement in carcinogenesis, but earlier studies have clearly suggested a regulatory role for these genes in PI3K/Akt pathway, which is known to be vital to the growth and survival of cancer cells [36].