INPP5K and neoplasm: To screen Hic1, Inpp5k and Myo1c genes for potential inactivating mutations, the entire coding regions of Hic1, Inpp5k and Myo1c, as well as the promoter region of Myo1c were sequenced using genomic DNA from tumor cell cultures and the parental rat strains (BDII, BN and SPRD) as template (Additional file 1: Table S1).