Subsequent analysis, however, revealed that Tp53 was not the only target [10], and in fact, the observed pattern for AI, chromosomal breaks and deletions suggested that major selection was directed against a region located close to, but distal of Tp53. This independent, commonly deleted chromosomal segment at RNO10q24-q25 is homologous to the frequently reported loci of tumor suppressor activity on 17p13.3 in several human malignancies [6–9]. Here, TP53 is linked to neoplasm.