2004), the effects of inhibiting macula densa-derived nNOS were investigated in our model of mild maternal renal insufficiency. Inhibition of NO production by 7NI treatment resulted in a significant increase in reactivity (ΔPSF and % ΔPSF increased) in both untreated and STNx fetuses, as well as an increase in sensitivity (reduced TP) as expected from earlier work (Thorup and Persson 1996a). Here, NOS1 is linked to Renal insufficiency.