Research performed by Kholodnyuk et al. showed that RTP3 (TMEM7) expression in 5 different RCC cell lines - KH39, CAKI-1, CAKI-2, KRC/Y and TK-10 was impaired in comparison to normal human kidney by RT-PCR [26] and was suggested to act as of tumor suppressor gene. This evidence concerns the gene RTP3 and renal cell carcinoma.