For example, p53 induces lncRNA-p21, which in turn represses numerous genes globally by recruiting the repressor protein hnRNP-K to modulate tumor progression [30], suggesting that lncRNAs may act as key regulatory nodes in multiple transcriptional pathways and serve as a signal or a convenient regulator to track the transcriptional activity of a target gene during cancer development. The gene discussed is TP53; the disease is cancer.