A study of polymorphisms further identified the biased distribution of single nucleotide polymorphisms (SNPs) in PPARD (peroxisome proliferator-activated receptors delta) rs2267669 and rs2076167 and APM1 (adipose most abundant gene transcript 1) rs7627128 and rs1063539 in the Yang-deficiency constitution; PPARD rs2076167 and APM1 rs266729 and rs7627128 in Phlegm-wetness constitution; and in PPARG (peroxisome proliferator-activated receptors gamma) Pro12Ala in the Yin-deficiency constitution [4]. The gene discussed is ADIPOQ; the disease is hyperinsulinemic hypoglycemia, familial, 4.