VEGFA and neoplasm: The mechanisms that underlie the anti-metastatic effects of sunitinib may include: 1) inhibition of VEGF-induced angiogenesis at the primary tumor site; 2) inhibition of VEGF-induced vascular leakage, which would otherwise increase susceptibility of tumor cell invasion; and 3) inhibition of non-VEGF-related invasive pathways both in tumor cells and in host cells as this drug targets multiple signaling pathways.