Interestingly, this list of putative epigenetic tumor suppressors included several histone methyltransferases (EZH1, SETD3, SETBP1, PRDM2 and PRDM5) and histone acetyltransferases (NCOA1, NCOA2, NCOA4, KAT5, KAT2B), but only one histone acetylation editor (SIRT1) and only one histone deacetylase (HDAC4). This evidence concerns the gene HDAC4 and neoplasm.