This analysis also revealed a number of epigenetic oncogenes (KDM1A, HDAC1, TDG) and tumor suppressors (KAT2B, PRDM5, DUSP1, EYA4) which did not correlate significantly with any of the others, suggesting that these may affect cancer DNAm patterns independently of each other (Fig. 4b). The gene discussed is HDAC1; the disease is cancer.