Meanwhile autophagy-related genes were induced in autopsy brains of AD patients3 and autophagosomes were co-localized not only with Aβ in AD but also with a-synuclein and tau aggregation in autopsy brains of Parkinson’s disease and frontotemporal lobar degeneration4, suggesting that misfolded disease proteins might generally induce autophagy. Here, MAPT is linked to Alzheimer disease.