Although the diagnostic and predictive values of plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) and cystatin-C (Cys-C) for sepsis-associated acute kidney injury (AKI) are generally accepted as reliable [1, 2], the diagnostic value of urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is attracting more attention. Here, CST3 is linked to acute kidney injury.