In the previous study, we have found that CCR9-CCL25 axis plays a significant role in survival of NSCLC cells by inhibiting cancer cell apoptosis both in vitro and in vivio through the activation of PI3K/Akt signaling pathway, and cell survival is essential for cancer cells to achieve invasion and metastasis [11]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.