Because gal-7R74S sensitized DU-145 cells to apoptosis without affecting their invasive behaviors or proliferation, leading to the augmentation of tumor growth in vivo, it is clear that alterations in the CRD of gal-7 that shift the balance towards CRD-independent binding partners not only have a profound effect on its intracellular distribution in cancer cells but also drive a phenotypic switch in its role in cancer. The gene discussed is LGALS7; the disease is cancer.