Of note, TKO-HFD mice had an overall glucose clearance comparable with that of chow-fed TKO and TWT mice, with a significantly lower blood glucose peak level after 15 and 30 min (Fig 3A and 3B), suggesting that lack of TIMP-1 protects against HFD-induced glucose intolerance. The gene discussed is TIMP1; the disease is Glucose intolerance.