Furthermore, we found that expression of Ppargc1a mRNA, recently linked to inhibition/modulation of obesity induced hepatic inflammation [29], was higher in TKO-HFD mice than in TWT-HFD mice, suggesting a mechanism for lack of hepatic inflammation in TKO-HFD mice. The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.