We also reported that resveratrol, a grape bioactive compound, suppressed colon cancer cell proliferation and elevated apoptosis even in the presence of IGF-1 (insulin like growth factor-1, a mitogen elevated during obesity) via suppression of IGF-1R/Akt/Wnt signaling pathways and activation of p53 [19]. Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.