Large amounts of transmitters, such as M-CSF, IL-6, IL-10, TGF-β, and COX-2, induce transformation of TAMs into M2 macrophages that secrete immune inhibitory chemokines with poorer antigen presenting and cytotoxic abilities, leading to tumor growth and metastasis [16, 21, 22, 27–34]. The gene discussed is CSF1; the disease is neoplasm.