TGFB1 and neoplasm: It is currently known that tumor environment contains large amount of transmitters such as M-CSF, IL-6, IL-10, TGF-β, and COX-2 that induces tumor megakaryocytes to differentiate into M2 macrophages, which, in addition to having poorer antigen-presenting and cytotoxic abilities, also secretes factors that inhibit immune cells, resulting in enhanced immune inhibitory effect of the tumor environment [16, 21, 22, 27–34].