Tumor cells secrete inflammatory cytokines, such as transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that stimulate differentiation of regulatory T and Treg cells [6–10], as well as differentiation of tumor-associated macrophages (TAMs) into M2 macrophages, leading to host immune response and subsequent tumor cell evasion of this immune surveillance and attack, in turn enhancing tumor growth and metastasis [1, 11–17]. This evidence concerns the gene IL10 and neoplasm.