Based on these results, oral intake of celecoxib or mushroom beta-glucan from Antrodia camphorata can decrease the gene expression of IL-6, IL-10, COX-2, and TGF-β and further decreases the proportion of M2 macrophages in tumor-bearing mice, as well as decreasing the secretion of cytokines, such as IL-10 and TGF-β that decreases the immune inhibitory effect in the tumor environment. This evidence concerns the gene IL6 and neoplasm.