The key findings in the present study were as follows: (1) the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml with a positive predictive value of 94 % and a negative predictive value of 36 %; (2) patients with high plasma prorenin concentration (>1,100 pg/ml) frequently suffered CAD; (3) the plasma prorenin concentration was positively correlated with the plasma renin concentration; (4) the plasma prorenin concentration was not correlated with LVEF, HbA1c, BNP or eGFR. The gene discussed is REN; the disease is coronary artery disorder.