Furthermore, PSMD9 SNP rs1043307/rs14259 (E197G A>G) is implicated in anti-depressant therapy response35, PSMD9 SNPs rs74421874 (IVS3+nt460 G>A), rs3825172 (IVS3+nt437 C>T) and rs14259 (E197G A>G) are linked to depression24 and anxiety25, and PSMD9 is strongly implicated in depression36 and schizophrenia37; thus, as all these disorders may share a common pathogenic inflammatory pathway, PSMD9 may well play a role in insomnia. The gene discussed is PSMD9; the disease is insomnia.