Because of its importance in Alzheimer’s disease, studies in the past have mainly focused on the functions of Fe65 in neuronal cells and have shown that Fe65 plays an important role in neurogenesis29, 30, neuronal migration and positioning27, 31, neurite outgrowth28, 32, synapse formation and learning33, 34, 35, 36, 37. Here, APBB1 is linked to early-onset autosomal dominant Alzheimer disease.