MMP-2 single nucleotide polymorphisms (SNPs) enable alterations in transcriptional regulation and thereby affect the function of its enzyme.10 These functional SNPs also affect MMP-2 gene transcription in an allele-specific fashion and are thus considered potential candidate to evaluate the associations with atherogenesis, tumor initiation, invasion, and metastasis.11 The gene discussed is MMP2; the disease is neoplasm.