AFP and hepatocellular carcinoma: Furthermore, histological assessment of HAC specimen shows similar morphological features to those of HCC.3 Immunohistochemical staining may be helpful for the diagnosis of HAC showing positive rates of AFP, Hep Par 1, and carcinoembryonic antigen (CEA) stains of 91.6%, 38.1%, and 78.7%, respectively.3 The prognosis of HAC is poor, with a life expectancy shorter than that of HCC.5